HuagongsheHuagongshe Chemistry Print Report · For research reference only
Itaconic acid → (RS)-1-[2,5-difluoro-4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Itaconic acid | HCID 811 | — |
| Reactant | 2,5-Difluoro-4-(3-fluorobenzyloxy)-phenylamine | HCID 21920054 | — |
| Product | (RS)-1-[2,5-difluoro-4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid | HCID 21920043 | 34.5% |
Reaction Steps
In an analogous manner to that described in Example 1a), 2,5-difluoro-4-(3-fluorobenzyloxy)-phenylamine was reacted with itaconic acid to yield (RS)-1-[2,5-difluoro-4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid (34.5% of theory) as a grey solid; MS: m/e=363 (M−H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122562B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-1f4601ae1fa34d498ba33f08f363fd91 |
| Source note | uspto-grants-2006_10 |