Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methylamine → (R)-1-[4-(3-Fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| 반응물 | (R)-1-(4-((3-Fluorobenzyl)oxy)phenyl)-5-oxopyrrolidine-3-carboxylic acid | HCID 67411567 | — |
| 생성물 | (R)-1-[4-(3-Fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methylamide | HCID 10020247 | — |
반응 단계
In an analogous manner to that described in Example 24 f), the condensation of the (R)-1-[4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid with methylamine using HBTU as the condensation agent yields the (R)-1-[4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methylamide as a white solid. MS: m/e=343 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07122562B2 |
| 출처 데이터셋 | uspto-grants-2006_10 |
| ORD ID | ord-cbc56a674e54488dbfca9d44bea1aecd |
| 출처 메모 | uspto-grants-2006_10 |