Sodium borohydride → HCID 21920057, compound

HRID 1244596Notes

Reaction equation

HRID 1244596 reaction equation
C[O:2][C:3]([CH:5]1[CH2:9][C:8](=[O:10])[N:7]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=3)=[CH:13][CH:12]=2)[CH2:6]1)=O.[BH4-].[Na+]>>[F:25][C:21]1[CH:20]=[C:19]([CH:24]=[CH:23][CH:22]=1)[CH2:18][O:17][C:14]1[CH:15]=[CH:16][C:11]([N:7]2[CH2:6][CH:5]([CH2:3][OH:2])[CH2:9][C:8]2=[O:10])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 4311764Sodium borohydrideHCID 68614055(RS)-1-[4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Product 1

HCID 21920057HCID 21920057, compound

Procedure

The title compound is prepared in analogy to Example 33a) from (RS)-1-[4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester and sodium borohydride. Yield: 82% of a colorless solid. MS: m/e=316.3 (M+H)+.

Sources & evidence

ORD record
ord-99a5f1e2562e40ab8a844efdbd2b499f
Source dataset
uspto-grants-2006_10
Patent number
US07122562B2

Reaction notes

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