Sodium Cyanide → HCID 9973515, compound

HRID 1244597Notes

Reaction equation

HRID 1244597 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][CH:23]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:17][CH:16]([CH2:18]O)[CH2:15][C:14]2=[O:20])=[CH:9][CH:8]=1.CS(Cl)(=O)=O.[C-:29]#[N:30].[Na+]>>[F:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][CH:23]=1)[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([N:13]2[C:14](=[O:20])[CH2:15][CH:16]([CH2:18][C:29]#[N:30])[CH2:17]2)=[CH:11][CH:12]=1

Participants

4

Reactant 3

HCID 8929Sodium CyanideHCID 31297Methanesulfonyl chlorideHCID 21920057HCID 21920057, compound

Product 1

HCID 9973515HCID 9973515, compound

Procedure

The title compound is prepared in analogy to Example 33b) from (RS)-1-[4-(3-fluoro-benzyloxy)-phenyl]-4-hydroxymethyl-pyrrolidin-2-one, methanesulfonyl chloride and sodium cyanide. Yield: 27% of a colorless solid. MS: m/e=325.2 (M+H)+.

Sources & evidence

ORD record
ord-c6f472ad3e2b4356bde99d5ec5574d90
Source dataset
uspto-grants-2006_10
Patent number
US07122562B2

Reaction notes

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