HuagongsheHuagongshe Chemistry Print Report · For research reference only
Itaconic acid → (RS)-1-{4-[2-(4-chloro-phenyl)-ethyl]-phenyl}-5-oxo-pyrrolidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Itaconic acid | HCID 811 | — |
| Reactant | 4-[2-(4-Chlorophenyl)ethyl]aniline | HCID 13135818 | — |
| Product | (RS)-1-{4-[2-(4-chloro-phenyl)-ethyl]-phenyl}-5-oxo-pyrrolidine-3-carboxylic acid | HCID 21920038 | — |
Reaction Steps
In an analogous manner to that described in Example 36 c), the reaction of 4-[2-(4-chloro-phenyl)-ethyl]-phenylamine with itaconic acid yields the (RS)-1-{4-[2-(4-chloro-phenyl)-ethyl]-phenyl}-5-oxo-pyrrolidine-3-carboxylic acid as an off-white solid; MS: m/e=342 (M−H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122562B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-d1d229eef5d545c889fd7d0230f3fa37 |
| Source note | uspto-grants-2006_10 |