Phenylglyoxal → 4-(7-Phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-ylmethyl)-phenol

HRID 1244634Notes

Reaction equation

HRID 1244634 reaction equation
O=[C:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH:3]=O.[NH2:11][N:12]1[C:16]([NH2:17])=[N:15][N:14]=[C:13]1[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=1>>[C:5]1([C:2]2[CH:3]=[N:11][N:12]3[C:13]([CH2:18][C:19]4[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=4)=[N:14][N:15]=[C:16]3[N:17]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 14090PhenylglyoxalHCID 219193134-[(4,5-Diamino-4H-1,2,4-triazol-3-yl)methyl]phenol

Product 1

HCID 219193254-(7-Phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-ylmethyl)-phenol

Procedure

General procedure A was followed with the reaction of oxo-phenyl-acetaldehyde and 4-(4,5-diamino-4H-[1,2,4]triazol-3-ylmethyl)-phenol to provide 4-(7-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-ylmethyl)-phenol and the desired product 4-(6-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-ylmethyl)-phenol (example 3).

Sources & evidence

ORD record
ord-b4986779e92949dcbc76c709fd1f9e9c
Source dataset
uspto-grants-2006_10
Patent number
US07122548B2

Reaction notes

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