Sodium Hydroxide → HCID 21920861, compound

HRID 1244675Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11]C)=[O:10])=[CH:4][C:3]=1[NH:13][C:14]([NH:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15].[OH-].[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][C:3]=1[NH:13][C:14]([NH:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 21920651HCID 21920651, compound

Product 1

HCID 21920861HCID 21920861, compound

Procedure

For ester cleavage, analogously to the above instructions, 2.47 mmol (790 mg) of methyl 4-chloro-3-[[[(phenylmethyl)amino]carbonyl]amino]benzeneacetate is saponified with 1N-NaOH. Product 5 is obtained without recrystallization. Yield: 693 mg of yellowish solid.

Sources & evidence

ORD record: ord-099b41f3251a4819a92eddcc8dfbd7a3
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07122570B2

Reaction notes

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