Sodium Hydroxide → HCID 21920742, compound

HRID 1244676Notes

Reaction equation

HRID 1244676 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11]C)=[O:10])=[CH:4][C:3]=1[NH:13][C:14]([NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)=[O:15].[OH-].[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][C:3]=1[NH:13][C:14]([NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)=[O:15]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 21920718HCID 21920718, compound

Product 1

HCID 21920742HCID 21920742, compound

Procedure

For ester cleavage, 2.47 mmol (790 mg) of methyl 4-chloro-3-[[(2-pyridinylamino)carbonyl]amino]benzeneacetate is saponified with 1N NaOH analogously to the instructions above. Product 7 is obtained without recrystallization. Yield: 693 mg of yellowish solid.

Sources & evidence

ORD record
ord-f894ba81bb254d0382d0d50f4fe9c6fe
Source dataset
uspto-grants-2006_10
Patent number
US07122570B2

Reaction notes

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