Dichloromethane methanol ammonium hydroxide → HCID 11394279, compound

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Reaction Steps

A solution of (RS,RS,RS)-[9,10-dimethoxy-3-(pyrrolidine-1-carbonyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido [2,1-a]isoquinolin-2-yl]-carbamic acid tert-butyl ester (55 mg, 0.12 mmol) in hydrogen chloride solution (4 M in dioxane, 1 mL) was stirred 1 h at r.t., then neutralized with CH2Cl2/MeOH/NH4OH 90:10:0.25 and evaporated. Chromatography of the residue (SiO2, CH2Cl2/MeOH/NH4OH 90:10:0.25) afforded the title compound (32 mg, 74%). Off-white foam, MS (ISP) 359.6 (M+).

Provenance & Evidence