Dichloromethane → HCID 68620864, compound

Participants

Reaction Steps

Acryloyl chloride (18 mg, 0.20 mmol) was added dropwise at 0° C. to a solution of (RS,RS,RS)-(3-but-3-enylamino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl)-carbamic acid tert-butyl ester (77 mg, 0.18 mmol) and triethylamine (20 mg, 0.20 mmol) in dichloromethane (1.5 mL). After 30 min at 0° C. the reaction mixture was partitioned between 2 M aq. sodium carbonate solution and ethyl acetate. The organic layer was washed with brine, dried (MgSO4), and evaporated. Chromatography (SiO2, CH2Cl2/MeOH/NH4OH 95:5:0.25) afforded the title compound (65 mg, 75%). White solid, MS (ISP) 486.5 (M+H)+.

Provenance & Evidence