Dichloromethane → HCID 68621897, compound

Participants

Reaction Steps

Tetraisopropyl orthotitanate (7.6 mg, 27 μmol) and Bis(tricyclohexylphosphine)-benzylideneruthenium(IV)dichloride (11 mg, 13 μmol) were added to a solution of (RS,RS,RS)-[3-(acryloyl-but-3-enyl-amino)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl]-carbamic acid tert-butyl ester (65 mg, 0.13 mmol) in dichloromethane (2.5 mL). The reaction mixture was stirred 45 min at r.t., then partitioned between ethyl acetate and water. The organic layer was washed with brine, dried (MgSO4), and evaporated. Chromatography (SiO2, CH2Cl2/MeOH/NH4OH 95:5:0.25) afforded the title compound (59 mg, 96%). White solid, MS (ISP) 458.4 (M+H)+.

Provenance & Evidence