Triethylamine → HCID 10289049, compound

Participants

Reaction Steps

N-[(1S,2S)-1-amino-2,3-dihydro-1H-inden-2-yl]-2,3-dichloro-4H-thieno[3,2-b]pyrrole-5-carboxamide trifluoroacetic acid salt (0.5 mmol) and Et3N (1.0 mmol) were dissolved in dry THF (5 mL), the appropriate isocyanate (1.0 mmol) was added and the reaction stirred at ambient temperature for 20 hours. EtOAc (15 mL) was added and the mixture washed with water (2×5 mL) brine (5 mL), dried (MgSO4) and the volatiles removed by evaporation under reduced pressure to give the title compound as a foam.

Provenance & Evidence