Dimethylformamide → HCID 10019598, compound

Participants

Reaction Conditions

Reaction Steps

The KOH pellets are added to the mixture of DMF and water, and the mixture is vigorously stirred for 5 minutes. After addition of the 5-benzyloxyindole, the mixture is stirred at room temperature for a further 45 minutes. Then, at an internal temperature of 10–20° C., 4-fluorobenzyl chloride is added dropwise while stirring. The mixture is then stirred at room temperature for a further 90 minutes. The mixture is cooled to 10° C., and 300 ml of water are added. It is cooled during this so that the internal temperature does not exceed 20° C. The mixture is stirred for 2 hours, and then the precipitate is filtered off with suction, washed with water and dried at 30° C. initially in circulating air and then in vacuo. The resulting product is very pure so that no additional purification operation is necessary.

Provenance & Evidence