6-Hydroxyquinoline → 2-(6-quinolinyloxy)-N-(1-methoxy-4-methylpent-2-yn-4-yl) 3-methoxypropionamide

Participants

Reaction Steps

In a similar procedure to Example 6 Stage 2, 6-hydroxyquinoline was reacted with 2-bromo-N-(1-methoxy-4-methylpent-2-yn-4-yl) 3-methoxypropionamide to give 2-(6-quinolinyloxy)-N-(1-methoxy-4-methylpent-2-yn-4-yl) 3-methoxypropionamide as a colourless oil. 1H NMR (CDCl3) δ: 1.60(3H, s); 1.62(3H, s); 3.34(3H, s); 3.44(3H, s); 3.90–3.94(2H, m); 4.06(2H, s); 4.76–4.80(1H, m); 6.60(1H, s); 7.14–7.16(1H, m); 7.36–7.40(1H, m); 7.46–7.50(1H, m); 8.04–8.08(2H, d); 8.82–8.84(1H, m).

Provenance & Evidence