HCID 58718575, compound → HCID 59101599, compound

HRID 1244824Notes

Reaction equation

HRID 1244824 reaction equation
C([O:3][C:4](=O)[CH2:5][C:6]1([CH2:13][N+:14]([O-])=O)[CH2:10][C@@H:9]([CH3:11])[C@H:8]([CH3:12])[CH2:7]1)C>CO.[Ni]>[CH3:12][C@H:8]1[C@H:9]([CH3:11])[CH2:10][C:6]2([CH2:13][NH:14][C:4](=[O:3])[CH2:5]2)[CH2:7]1

Participants

4

Reactant 1

HCID 58718575HCID 58718575, compound

Product 1

HCID 59101599HCID 59101599, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

The nitroester (3) (1.14 g, 4.7 mmol) was dissolved in methanol (50 mL) and shaken over Raney nickel catalyst under an atmosphere of hydrogen (40 psi) at 30° C. After 5 hours, the catalyst was removed by filtration through celite. The solvent was removed in vacuo to give 746 mg (95%) of a pale yellow oil which solidified on standing.

Workup

  1. customthe catalyst was removed by filtration through celite
  2. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-60dc8f6d7f6f427fb956d9f3cc3f3139
Source dataset
uspto-grants-2006_10
Patent number
US07122678B2

Reaction notes

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