HCID 58718575, compound → HCID 59101599, compound

HRID 1244827Notes

Reaction equation

HRID 1244827 reaction equation
C([O:3][C:4](=O)[CH2:5][C:6]1([CH2:13][N+:14]([O-])=O)[CH2:10][C@@H:9]([CH3:11])[C@H:8]([CH3:12])[CH2:7]1)C>CO.[Ni]>[CH3:12][C@H:8]1[C@H:9]([CH3:11])[CH2:10][C:6]2([CH2:13][NH:14][C:4](=[O:3])[CH2:5]2)[CH2:7]1

Participants

4

Reactant 1

HCID 58718575HCID 58718575, compound

Product 1

HCID 59101599HCID 59101599, compoundYield 99.7%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

The nitroester (3) (0.83 g, 3.4 mmol) was dissolved in methanol (30 mL) and shaken over Raney nickel catalyst under an atmosphere of hydrogen (40 psi) at 30° C. After 4 hours, the catalyst was removed by filtration through celite. The solvent was removed in vacuo to give 567 mg (99%) of a pale yellow oil which solidified on standing.

Workup

  1. customthe catalyst was removed by filtration through celite
  2. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-d1cfb707e8e948b0b38f38829daf7b8d
Source dataset
uspto-grants-2006_10
Patent number
US07122678B2

Reaction notes

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