HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Isopropylidene-4-methoxy-1,3-dihydro-indol-2-one → 3-Isopropyl-4-methoxy-1,3-dihydro-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Isopropylidene-4-methoxy-1,3-dihydro-indol-2-one | HCID 21923245 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Isopropyl-4-methoxy-1,3-dihydro-indol-2-one | HCID 21923248 | 80.2% |
Reaction Steps
A mixture of 3-isopropylidene-4-methoxy-1,3-dihydro-indol-2-one (700 mg, 3.4 mmol) and 5% palladium on carbon (88 mg) in ethanol (25 mL) is hydrogenated at 60 psi overnight. Filtration and removal of the solvent in vacuo provided 560 mg (79%) of 3-isopropyl-4-methoxy-1,3-dihydro-indol-2-one. MS (ESI+) 206.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122680B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-7ec73e1fa0a64052a7f8ae5efcf78d89 |
| Source note | uspto-grants-2006_10 |