Cyclobutanone → HCID 58718608, compound

Participants

Reaction Steps

tert-butyl (3S)-3-(cyclobutylamino)pyrrolidine-1-carboxylate was prepared by a method similar to that described in preparation 1 using tert-butyl (3S)-3-aminopyrrolidine-1-carboxylate and cyclobutanone (15 equivalents: 10 eq. added first, 5 eq. added before the second azeotropic removal of water) except that the crude product was purified by column chromatography on silica gel to yield the title compound, 542 mg (28%).

Provenance & Evidence