Tetrahydro-4H-pyran-4-one → HCID 58718610, compound

Participants

Reaction Steps

tert-butyl (3S)-3-aminopyrrolidine-1-carboxylate was added to a solution of tetrahydro-4H-pyran-4-one and 10% Pd/C (300 mg) in ethanol and the reaction mixture left under about 415 kPa (about 60 psi) of hydrogen gas for 18 hours. The reaction mixture was filtered through Arbocel®, washing through thoroughly with ethyl acetate. The filtrate was concentrated in vacuo and the crude product purified by column chromatography on silica gel to yield the desired product, 6.7 g (61%).

Provenance & Evidence