Triethylamine → HCID 58646897, compound

Participants

Reaction Steps

tert-butyl (3S)-3-[(cyclobutylmethyl)amino]pyrrolidine-1-carboxylate (0.80 g, 3.15 mmol) in toluene (10 ml) was treated with 2-(trifluoromethyl)benzoyl chloride (0.55 ml, 3.78 mmol) and triethylamine (0.88 ml, 6.3 mmol). The solution was stirred for 18 hours at room temperature and the solvent removed under reduced pressure. The crude product was purified by column chromatography on silica gel using a gradient of pentane:ethylacetate (4:1 by volume) changing to pentane:ethylacetate (1:1 by volume) to afford the title compound as a colorless oil (1.40 g, crude) which is used directly in the next step.

Provenance & Evidence