3-Iodobenzylamine → HCID 21923057, compound

HRID 1244898Notes

Reaction equation

HRID 1244898 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[C:4](Cl)[N:3]=1.[I:17][C:18]1[CH:19]=[C:20]([CH2:24][NH2:25])[CH:21]=[CH:22][CH:23]=1>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[C:4]([NH:25][CH2:24][C:20]2[CH:21]=[CH:22][CH:23]=[C:18]([I:17])[CH:19]=2)[N:3]=1

Participants

4

Reactant 2

HCID 970123-IodobenzylamineHCID 21923063HCID 21923063, compound

Product 1

HCID 21923057HCID 21923057, compoundYield 53,188.898%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

The operation is carried out as in Stage 2 of Example 2 starting from 133 mg of the product obtained in Stage 1 of Example 2 and 2 ml of butanol and using 0.2 mg of 3-iodo-benzenemethanamine (1.1 eq) in place of the benzylamine. In this way 208 mg of expected product is obtained in the form of white crystals.

Sources & evidence

ORD record
ord-67eb0123cc2f466f8a33ac4fe5a9500c
Source dataset
uspto-grants-2006_10
Patent number
US07122669B1

Reaction notes

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