HCID 21922955, compound → HCID 18457595, compound

HRID 1244900Notes

Reaction equation

HRID 1244900 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[C:4]([NH:16][CH2:17][CH2:18][CH3:19])[N:3]=1.[NH2:20][C@H:21]1[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]1>>[ClH:1].[ClH:1].[NH2:20][CH:21]1[CH2:26][CH2:25][CH:24]([NH:27][C:2]2[N:10]=[C:9]3[C:5]([N:6]=[CH:7][N:8]3[CH:11]3[CH2:15][CH2:14][O:13][CH2:12]3)=[C:4]([NH:16][CH2:17][CH2:18][CH3:19])[N:3]=2)[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 21922955HCID 21922955, compoundHCID 178511674HCID 178511674, compound

Product 1

HCID 18457595HCID 18457595, compoundYield 93.3%

Procedure

The operation is carried out as in Stage 3 of Example 2 starting from 109 mg of the product obtained in Stage 1 above and 445 mg of trans-1,4-diaminocyclohexane. After purification on silica eluting with methanol/ammonium hydroxide (NH4OH) in a proportion of 98/2, salification is carried out with 1.4 N hydrochloric acid in ethanol. In this way 78 mg of expected product is obtained in the form of crystals.

Workup

  1. customAfter purification on silica eluting with methanol/ammonium hydroxide (NH4OH) in a proportion of 98/2, salification

Sources & evidence

ORD record
ord-18f58a037aaa40c3944e64ffdbcae569
Source dataset
uspto-grants-2006_10
Patent number
US07122669B1

Reaction notes

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