HCID 21923045, compound → HCID 178478596, compound

Participants

Reaction Steps

The operation is carried out as in Stage 3 of Example 7 starting from 320 mg of the product obtained in Stage 1 above and 770 mg of trans-1,4-diaminocyclohexane and the reaction medium is heated to approximately 140° C. for 3 hours. After purification by chromatography on silica eluting with methylene chloride/methanol/ammonium hydroxide in a proportion of 85/25/1.5 salification is carried out with 1.4N HCl/EtOH, followed by filtering, washing with 5 ml EtOH then drying at ˜50° C. In this way 166 mg of expected product is obtained.

Provenance & Evidence