HCID 21923048, compound → HCID 18457565, compound

HRID 1244933Notes

Reaction equation

HRID 1244933 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH3:14])[CH2:12][CH3:13])=[C:4]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:3]=1.[NH2:22][C@H:23]1[CH2:28][CH2:27][C@H:26]([NH2:29])[CH2:25][CH2:24]1>>[ClH:1].[ClH:1].[NH2:22][CH:23]1[CH2:28][CH2:27][CH:26]([NH:29][C:2]2[N:10]=[C:9]3[C:5]([N:6]=[CH:7][N:8]3[CH:11]([CH3:14])[CH2:12][CH3:13])=[C:4]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[N:3]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 21923048HCID 21923048, compoundHCID 178511674HCID 178511674, compound

Product 1

HCID 18457565HCID 18457565, compoundYield 127%

Procedure

The operation is carried out as in Stage 2 of Example 44 starting from 166 mg of the product obtained in Stage 1 above and 629 mg of trans-1,4-diaminocyclohexane. In this way 158 mg of expected product is obtained in the form of crystals.

Sources & evidence

ORD record
ord-5ad8d3f32219412c99cb8deebec7e16f
Source dataset
uspto-grants-2006_10
Patent number
US07122669B1

Reaction notes

Loading…