HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 21923079, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | p-(Trifluoromethoxy)benzaldehyde | HCID 69573 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | N-(2-aminoethyl)-2-chloro-9-cyclopentyl-9H-purin-6-amine | HCID 21922924 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 21923079 | HCID 21923079 | — |
Reaction Steps
281 mg of the product obtained in Stage 1 of Example 7, 4 ml of methanol, 0.16 ml of 4-trifluoromethoxy-benzaldehyde and 0.2 ml of acetic acid are mixed together, the reaction medium is agitated for 2 hours and 30 minutes, 0.1 g of NaBH3CN is added and agitation is carried out at ambient temperature for 1 hour. The solvent is evaporated off, the residue is chromatographed on silica eluting with CH2Cl2/methanol/ammonium hydroxide (95/0.5/0.33) and 129 mg of expected product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122669B1 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-758a53d2f2ab488ba3fa2e49e079228c |
| Source note | uspto-grants-2006_10 |