HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-chloro-9-cyclopentyl-N-[2-[[(3,5-dichlorophenyl) methyl]-amino]-ethyl]-9H-purin-6-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 3,5-Dichlorobenzaldehyde | HCID 35746 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | N-(2-aminoethyl)-2-chloro-9-cyclopentyl-9H-purin-6-amine | HCID 21922924 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-chloro-9-cyclopentyl-N-[2-[[(3,5-dichlorophenyl) methyl]-amino]-ethyl]-9H-purin-6-amine | HCID 18457538 | — |
Reaction Steps
281 mg of the product obtained in Stage 1 of Example 7, 4 ml of methanol, 0.16 ml of 3,5-dichloro-benzaldehyde and 0.2 ml of acetic acid are mixed together, the reaction medium is agitated for 2 hours and 30 minutes, 0.1 g of NaBH3CN is added and agitation is carried out at ambient temperature for 1 hour. After evaporating the solvent, the residue is chromatographed on silica eluting with CH2Cl2/methanol/ammonium hydroxide (95/0.5/0.33) and 119 mg of expected product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122669B1 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-9bc2dbf9c37e4624b22989ee585dbe06 |
| Source note | uspto-grants-2006_10 |