HCID 21922973, compound → HCID 178478729, compound

Participants

Reaction Conditions

Reaction Steps

800 mg of trans-1,4-diaminocyclohexane is taken to approximately 140° C. then 286 mg of the product obtained in Stage 1 above is added, the reaction medium is maintained under agitation at 140° C. for 5 hours then left to return to ambient temperature. Then 15 ml of water is added, followed by extracting with dichloromethane, drying and evaporating the solvent. The residue is chromatographed on silica (eluent: MeOH/NH4OH 98/2), followed by taking up in 4 ml of an ethanolic solution of hydrochloric acid, evaporating the solvents, drying under reduced pressure to 50° C. and 143 mg of expected product is recovered.

Provenance & Evidence