HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-chloro-N-[2-[(2-chloro-9-cyclopentyl-9H-purin-6-yl)-amino]-ethyl]-4-nitro-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloro-3-nitrobenzoyl chloride | HCID 12627413 | — |
| Reactant | N-(2-aminoethyl)-2-chloro-9-cyclopentyl-9H-purin-6-amine | HCID 21922924 | — |
| Product | 2-chloro-N-[2-[(2-chloro-9-cyclopentyl-9H-purin-6-yl)-amino]-ethyl]-4-nitro-benzamide | HCID 21922962 | — |
Reaction Steps
280 mg of the product obtained in Stage 1 of Example 7, 4 ml of methylene chloride, 0.28 ml of triethylamine and 264 mg of 2-chloronitrobenzoyl chloride are mixed together then the reaction medium is agitated at ambient temperature for 3 hours. Then 2 ml of water is added, followed by extracting with methylene chloride, drying and evaporating the solvents. In this way 295 mg of expected product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122669B1 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-f5d30d40e3224d30a95244b6500caf97 |
| Source note | uspto-grants-2006_10 |