HCID 21923043, compound → HCID 178478866, compound

Participants

Reaction Steps

400 mg of trans-1,4-diaminocyclohexane is taken to approximately 150° C. then 275 mg of the product obtained in Stage 1 above is added, the reaction medium is left under agitation for 3 hours then left to return to ambient temperature, followed by evaporating the solvents, and chromatography on silica (eluent: MeOH/NH4OH 98/2). The residue is taken up in an ethanolic solution of hydrochloric acid, followed by evaporating the solvents, impasting in ether, separating, drying under reduced pressure at ambient temperature and 205 mg of expected product is recovered.

Provenance & Evidence