反应详情

186 mg (1.40 mmol) of 2-nitroethyl acetate were added to a solution of 300 mg (0.93 mmol) of 3-(4-fluorophenyl)-1-(piperidin-4-yl)-2-(pyridin-4-yl)-1H-pyrrole (prepared as described in Example 13 above) in 6 ml of ethanol. The resulting mixture was stirred at room temperature for 30 minutes, after which the solvent was distilled off under reduced pressure. A saturated aqueous solution of sodium hydrogencarbonate was added to the residue and then this was extracted with ethyl acetate. The organic extract was washed with water, dried over anhydrous magnesium sulfate and then concentrated by evaporation under reduced pressure. The residual solid was washed with diethylether to give 280 mg (yield 76%) of the title compound as a white powder.

1. distillationafter which the solvent was distilled off under reduced pressure
2. additionA saturated aqueous solution of sodium hydrogencarbonate was added to the residue
3. extractionthis was extracted with ethyl acetate
4. extractionThe organic extract
5. washwas washed with water
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationconcentrated by evaporation under reduced pressure
8. washThe residual solid was washed with diethylether