Aluminium lithium hydride → HCID 21922863, compound

HRID 1245002Notes

Reaction equation

HRID 1245002 reaction equation
C([O:3][C:4]([CH2:6][CH2:7][C:8]1[C:9]([C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)=[C:10]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[NH:11][CH:12]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[F:19][C:16]1[CH:15]=[CH:14][C:13]([C:10]2[NH:11][CH:12]=[C:8]([CH2:7][CH2:6][CH2:4][OH:3])[C:9]=2[C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21922683HCID 21922683, compound

Product 1

HCID 21922863HCID 21922863, compoundYield 91%

Procedure

In a similar manner to that described in Example 1(vi) above, 4-(2-ethoxycarbonylethyl)-2-(4-fluorophenyl)-3-(pyridin-4-yl)-1H-pyrrole [prepared as described in step 23(ii) above] was reduced using lithium aluminum hydride to afford the title compound (yield 91%) as a pale brown powder.

Sources & evidence

ORD record
ord-a7d2d8768d6043c29a0db68260b29622
Source dataset
uspto-grants-2006_10
Patent number
US07122666B2

Reaction notes

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