HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → HCID 9880738, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | HCID 21922728 | HCID 21922728 | — |
| Reactant | TFA triethylsilane | HCID 131722655 | — |
| Product | HCID 9880738 | HCID 9880738 | 91% |
Reaction Steps
In a similar manner to that described in Example 9(iii) above, using 2-(4-fluorophenyl)- 4-(4-hydroxy-1-methylpiperidin-4-yl)-3-(pyridin-4-yl)-1-triisopropylsilyl- 1H-pyrrole [prepared as described in step 32(i) above], dehydration with triethylsilane/trifluoroacetic acid and desilylation with tetrabutylammonium fluoride were carried out to give the title compound (yield 91%) as a pale yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122666B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-ded32cca04dc43428f651850d31ca3e4 |
| Source note | uspto-grants-2006_10 |