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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1245005Generated: October 31, 2026

Tetrabutylammonium Fluoride → HCID 9880738, compound

https://huagongshe.com/reaction/1245005

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrabutylammonium FluorideHCID 2724141—
ReactantHCID 21922728HCID 21922728—
ReactantTFA triethylsilaneHCID 131722655—
ProductHCID 9880738HCID 988073891%

Reaction Steps

In a similar manner to that described in Example 9(iii) above, using 2-(4-fluorophenyl)- 4-(4-hydroxy-1-methylpiperidin-4-yl)-3-(pyridin-4-yl)-1-triisopropylsilyl- 1H-pyrrole [prepared as described in step 32(i) above], dehydration with triethylsilane/trifluoroacetic acid and desilylation with tetrabutylammonium fluoride were carried out to give the title compound (yield 91%) as a pale yellow powder.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07122666B2
Source datasetuspto-grants-2006_10
ORD IDord-ded32cca04dc43428f651850d31ca3e4
Source noteuspto-grants-2006_10