HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,4R)-1-[(benzyloxy)carbonyl]-4-methoxypyrrolidine-2-carboxylic acid → (8aS)-2,2-Difluoro-1,2,3,5,6,7,8,8a-octahydroindolizin-7-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,4R)-1-[(benzyloxy)carbonyl]-4-methoxypyrrolidine-2-carboxylic acid | HCID 12849521 | — |
| Reactant | 4-(1-Allyloxycarbonyl-1,2,3,6-tetrahydropyridin-4-yl]-2-(4-fluorophenyl)-3-(2-fluoropyridin-4-yl)-1H-pyrrole | HCID 21922685 | — |
| Reactant | (S)-1-((Benzyloxy)carbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid | HCID 53909714 | — |
| Product | (8aS)-2,2-Difluoro-1,2,3,5,6,7,8,8a-octahydroindolizin-7-one | HCID 57457954 | — |
Reaction Steps
In a similar manner to the procedures described in Preparative Examples 1(i)′, (ii) and (iii) above, reactions were carried out successively, using (2S)-1-benzyloxycarbonyl-4,4-difluoroproline as a starting material instead of (2S,4R)-1-benzyloxycarbonyl-4-methoxyproline, to give the title compound as a pale yellow oil (total yield for the 3 steps: 14%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122666B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-4d33df723ad049658393bd644b36894e |
| Source note | uspto-grants-2006_10 |