HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyloxycarbonyl-2-(3-ethoxycarbonyl-2-oxopropyl)indoline → 2-(3-Ethoxycarbonyl-2-oxopropyl)indoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyloxycarbonyl-2-(3-ethoxycarbonyl-2-oxopropyl)indoline | HCID 21922651 | — |
| Reactant | (2S,4R)-1-Benzyloxycarbonyl-2-(3-ethoxycarbonyl-2-oxopropyl)-4-methoxypyrrolidine | HCID 57501855 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Product | 2-(3-Ethoxycarbonyl-2-oxopropyl)indoline | HCID 21922622 | — |
Reaction Steps
In a similar manner to that described in Preparative Example 1(iii)′ above, a debenzylation reaction using hydrogen gas and palladium hydroxide on carbon was performed, using 1-benzyloxycarbonyl-2-(3-ethoxycarbonyl-2-oxopropyl)indoline [obtained as described in Preparative Example 5(iii)′ above] instead of (2S, 4R)-1-benzyloxycarbonyl-2-(3-ethoxycarbonyl-2-oxopropyl)-4-methoxypyrrolidine, to give the title compound as an orange oil (yield: quantitative).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122666B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-d92abf15123f43ccb0d11987ad28a383 |
| Source note | uspto-grants-2006_10 |