(2S,4R)-1-Benzyloxycarbonyl-2-(3-ethoxycarbonyl-2-oxopropyl)-4-methoxypyrrolidine → (2r,8As)-2-phenyl-1,2,3,5,6,7,8,8a-octahydroindolizin-7-one

Participants

Reaction Steps

In a similar manner to that described in Preparative Example 1(iii)′ above, a reaction was conducted, using (2S,4R)-1-benzyloxycarbonyl-2-(3-ethoxycarbonyl-2-oxopropyl)-4-phenylpyrrolidine [obtained as described in Preparative Example 6(iv)′ above] instead of (2S,4R)-1-benzyloxycarbonyl-2-(3-ethoxycarbonyl-2-oxopropyl)-4-methoxypyrrolidine, to give the title compound as a pale yellow oil (yield: 27%).

Provenance & Evidence