(2S,4R)-1-Benzyloxycarbonyl-2-(3-ethoxycarbonyl-2-oxopropyl)-4-methoxypyrrolidine → HCID 57457956, compound

HRID 1245035Notes

Reaction equation

HRID 1245035 reaction equation
C(OC([N:11]1[CH2:15][CH:14]([CH3:16])[CH2:13][C@H:12]1[CH2:17][C:18](=[O:25])[CH2:19][C:20](OCC)=O)=O)C1C=CC=CC=1.C(OC(N1C[C@H](OC)C[C@H]1CC(=O)CC(OCC)=O)=O)C1C=CC=CC=1>>[CH3:16][CH:14]1[CH2:15][N:11]2[C@H:12]([CH2:17][C:18](=[O:25])[CH2:19][CH2:20]2)[CH2:13]1

Participants

3

Reactant 2

HCID 57501855(2S,4R)-1-Benzyloxycarbonyl-2-(3-ethoxycarbonyl-2-oxopropyl)-4-methoxypyrrolidineHCID 60204908(2s)-1-Benzyloxycarbonyl-2-(3-ethoxycarbonyl-2-oxopropyl)-4-methylpyrrolidine

Product 1

HCID 57457956HCID 57457956, compoundYield 34%

Procedure

In a similar manner to that described in Preparative Example 1(iii)′ above, a reaction was performed, using (2S)-1-benzyloxycarbonyl-2-(3-ethoxycarbonyl-2-oxopropyl)-4-methylpyrrolidine [obtained as described in Preparative Example 8(v)′ above] instead of (2S,4R)-1-benzyloxycarbonyl-2-(3-ethoxycarbonyl-2-oxopropyl)-4-methoxypyrrolidine, to give the title compound as a colorless oil (yield: 34%).

Workup

  1. customobtained

Sources & evidence

ORD record
ord-33e5893c2de446e2a06ab0c117091cd2
Source dataset
uspto-grants-2006_10
Patent number
US07122666B2

Reaction notes

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