(S)-1-Benzyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylate → HCID 57457964, compound

HRID 1245052Notes

Reaction equation

HRID 1245052 reaction equation
CO[C:3](=O)[C@@H:4]1[CH2:8][C:7](=[CH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:6][N:5]1[C:16](OCC1C=CC=CC=1)=O.C[O:28][C:29](=O)[C@@H:30]1CC(=C)CN1C(OCC1C=CC=CC=1)=O>>[CH2:9]([C@@H:7]1[CH2:6][N:5]2[C@H:4]([CH2:3][C:29](=[O:28])[CH2:30][CH2:16]2)[CH2:8]1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 54190049(S)-1-Benzyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylateHCID 69559065HCID 69559065, compound

Product 1

HCID 57457964HCID 57457964, compoundYield 4%

Procedure

In a similar manner to the procedures described in Preparative Examples 8(ii)′, 8(iii)′, 8(iv)′, 8(v)′ and 8(vi)′ above, reactions were conducted in turn, using (S)-1-benzyloxycarbonyl-4-benzylideneproline methyl ester [prepared as described in Preparative Example 26′ above] instead of (S)-1-benzyloxycarbonyl-4-methylideneproline methyl ester, to give the title compound as a brown oil (yield: 4%).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-b27133d29bd64dc49a3dba2fd976ba7e
Source dataset
uspto-grants-2006_10
Patent number
US07122666B2

Reaction notes

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