4-(Trifluoromethyl)phenylboronic acid → HCID 58717751, compound

HRID 1245054Notes

Reaction equation

HRID 1245054 reaction equation
C[O:2][C:3](=[O:26])[C@@H:4]([NH:13][C:14]([C:16]1[N:17]=[CH:18][C:19]2[C:24]([CH:25]=1)=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:15])[CH2:5][C:6]1[CH:11]=[CH:10][C:9](Br)=[CH:8][CH:7]=1.[F:27][C:28]([F:39])([F:38])[C:29]1[CH:34]=[CH:33][C:32](B(O)O)=[CH:31][CH:30]=1>>[CH:18]1[C:19]2[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:25]=[C:16]([C:14]([NH:13][C@@H:4]([CH2:5][C:6]2[CH:11]=[CH:10][C:9]([C:32]3[CH:33]=[CH:34][C:29]([C:28]([F:39])([F:38])[F:27])=[CH:30][CH:31]=3)=[CH:8][CH:7]=2)[C:3]([OH:2])=[O:26])=[O:15])[N:17]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 69609702HCID 69609702, compound

Product 1

HCID 58717751HCID 58717751, compoundYield 80%

Procedure

The resulting amide (100 mg, 0.24 mmol) was reacted with 4-trifluoromethylphenyl boronic acid (95 mg, 0.5 mmol) as described in general procedure D yielding the title compound (80 mg, 80%) as a white solid.

Sources & evidence

ORD record
ord-3638abd730f14eb3961c2af43e40f1bd
Source dataset
uspto-grants-2006_10
Patent number
US07122580B2

Reaction notes

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