Tyrosine Methyl Ester → HCID 69610138, compound

HRID 1245056Notes

Reaction equation

HRID 1245056 reaction equation
[CH3:1][O:2][C:3](=[O:14])[C@@H:4]([NH2:13])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.[CH:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[C:17]([C:25](O)=[O:26])[N:16]=1>>[CH3:1][O:2][C:3](=[O:14])[C@@H:4]([NH:13][C:25]([C:17]1[N:16]=[CH:15][C:24]2[C:19]([CH:18]=1)=[CH:20][CH:21]=[CH:22][CH:23]=2)=[O:26])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 70652Tyrosine Methyl EsterHCID 124656Isoquinoline-3-carboxylic acid

Product 1

HCID 69610138HCID 69610138, compoundYield 100.1%

Procedure

3-(4-Hydroxyphenyl)-(2S)-[(isoquinoline-3-carbonyl)-amino]-propionic acid methyl ester (807 mg, 90%) was prepared from (2S)-amino-3-(4-hydroxy-phenyl)-propionic acid methyl ester (500 mg, 3.0 mmol) and isoquinoline-3-carboxylic acid (530 mg, 2.3 mmol) according to general procedure A.

Sources & evidence

ORD record
ord-751606ba90a3422fa0c96660c9a4c63a
Source dataset
uspto-grants-2006_10
Patent number
US07122580B2

Reaction notes

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