5-Fluoro-2-nitrophenol → HCID 21921907, compound

Participants

Reaction Conditions

Reaction Steps

To 4.0 g (4.0 mmol) of resin-bound 5-fluoro-2-nitro-phenol prepared as generally described in Example 37 in 8.0 mL of DMF were added 1.34 g (8.0 mmol) of methyl 4-hydroxyphenylacetate, and 1.20 g (8.0 mmol) of K2CO3. The mixture was heated to 110° C. for 12 h. The resin was washed with H2O, DMF, MeOH, DCM three times of each, and was hydrolyzed by LiOH/H2O/THF/ethanol at rt for 12 h to give the resin-bound [4-(3-hydroxy-4-nitro-phenoxy)-phenyl]-acetic acid.

Provenance & Evidence