Boronic acid, (4-ethylphenyl)- → HCID 68870469, compound

HRID 1245091Notes

Reaction equation

HRID 1245091 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5](OCCCCCCC)=[C:6]([CH:38]=1)[C:7]([NH:9][C@@H:10]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2OC2C=CC(C(F)(F)F)=CC=2)=[CH:17][CH:16]=1)[C:11]([OH:13])=[O:12])=[O:8].[CH2:47]([C:49]1[CH:54]=[CH:53][C:52](B(O)O)=[CH:51][CH:50]=1)[CH3:48]>>[C:18]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:17]=[CH:16][C:15]([CH2:14][C@H:10]([NH:9][C:7]([C:6]2[CH:38]=[C:2]([C:51]3[CH:52]=[CH:53][CH:54]=[C:49]([CH2:47][CH3:48])[CH:50]=3)[CH:3]=[CH:4][CH:5]=2)=[O:8])[C:11]([OH:13])=[O:12])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 2734352Boronic acid, (4-ethylphenyl)-HCID 58717681HCID 58717681, compound

Product 1

HCID 68870469HCID 68870469, compoundYield 97.7%

Procedure

3-Biphenyl-4-yl-(2S)-[(3-bromo-benzoyl-amino)-propionic acid (100 mg, 0.23 mmol) was reacted with 4-ethyl phenyl boronic acid (0.145 mg, 0.69 mmol) by following general procedure D yielding the title compound (101 mg, 85%) as a white solid.

Sources & evidence

ORD record
ord-526f027626724f4e827a2fb468e501fb
Source dataset
uspto-grants-2006_10
Patent number
US07122580B2

Reaction notes

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