4-tert-Butylphenylboronic acid → HCID 58718060, compound

HRID 1245092Notes

Reaction equation

HRID 1245092 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5](OCCCCCCC)=[C:6]([CH:38]=1)[C:7]([NH:9][C@@H:10]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2OC2C=CC(C(F)(F)F)=CC=2)=[CH:17][CH:16]=1)[C:11]([OH:13])=[O:12])=[O:8].[C:47]([C:51]1[CH:56]=[CH:55][C:54](B(O)O)=[CH:53][CH:52]=1)([CH3:50])([CH3:49])[CH3:48]>>[C:18]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:19]=[CH:20][C:15]([CH2:14][C@H:10]([NH:9][C:7]([C:6]2[CH:38]=[C:2]([C:54]3[CH:55]=[CH:56][C:51]([C:47]([CH3:50])([CH3:49])[CH3:48])=[CH:52][CH:53]=3)[CH:3]=[CH:4][CH:5]=2)=[O:8])[C:11]([OH:13])=[O:12])=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 27343204-tert-Butylphenylboronic acidHCID 58717681HCID 58717681, compound

Product 1

HCID 58718060HCID 58718060, compoundYield 86.5%

Procedure

3-Biphenyl-4-yl-(2S)-[(3-bromo-benzoyl-amino)-propionic acid (100 mg, 0.23 mmol) was reacted with 4-tert-butyl phenyl boronic acid (0.125 mg, 0.69 mmol) by following general procedure D yielding the title compound (95 mg, 85%) as a white solid.

Sources & evidence

ORD record
ord-e8d47d5d01a140f6b31be2b25895f0c3
Source dataset
uspto-grants-2006_10
Patent number
US07122580B2

Reaction notes

Loading…