2-Amino-5-bromobenzoic acid → HCID 68870114, compound

HRID 1245101Notes

Reaction equation

HRID 1245101 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:27])[C@@H:5]([NH2:26])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:9][CH:8]=1.[Br:28][C:29]1[CH:30]=[CH:31][C:32]([NH2:38])=[C:33]([CH:37]=1)[C:34](O)=[O:35]>>[CH3:2][O:3][C:4](=[O:27])[C@@H:5]([NH:26][C:34](=[O:35])[C:33]1[CH:37]=[C:29]([Br:28])[CH:30]=[CH:31][C:32]=1[NH2:38])[CH2:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 798582-Amino-5-bromobenzoic acidHCID 68869458HCID 68869458, compound

Product 1

HCID 68870114HCID 68870114, compoundYield 80%

Procedure

(S)-(2-Amino-5-bromo-benzoylamino)-3-(2′-phenoxy-biphenyl-4-yl)-propionic acid methyl ester (1.53 g, 80%) was prepared from (2S)-Amino-3-(2′-phenoxy-biphenyl-4-yl)-propionic acid methyl ester HCl salt (1.0 g, 2.6 mmol, 5-bromo-2-amino-benzoic acid (0.5 g, 2.9 mmol) as described in general procedure A.

Sources & evidence

ORD record
ord-8ad692cf1d7247e2b0617f37f25f029a
Source dataset
uspto-grants-2006_10
Patent number
US07122580B2

Reaction notes

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