2-Amino-5-chlorobenzoic acid → HCID 68859581, compound

HRID 1245114Notes

Reaction equation

HRID 1245114 reaction equation
[CH3:1][O:2][C:3](=[O:26])[C@@H:4]([NH2:25])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:8][CH:7]=1.[Cl:27][C:28]1[CH:29]=[CH:30][C:31]([NH2:37])=[C:32]([CH:36]=1)[C:33](O)=[O:34]>>[CH3:1][O:2][C:3](=[O:26])[C@@H:4]([NH:25][C:33](=[O:34])[C:32]1[CH:36]=[C:28]([Cl:27])[CH:29]=[CH:30][C:31]=1[NH2:37])[CH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 124762-Amino-5-chlorobenzoic acidHCID 58717858HCID 58717858, compound

Product 1

HCID 68859581HCID 68859581, compound

Procedure

(2S)-(2-Amino-5-chloro-benzoylamino)-3-(2′-phenoxy-biphenyl-4-yl)-propionic acid methyl ester was prepared (0.6 g, 80%) from (2S)-Amino-3-(2′-phenoxy-biphenyl-4-yl)-propionic acid methyl ester (0.5 g, 1.5 mmol), 5-chloro-2-amino-benzoic acid (0.28 g, 1.65 mmol) as desribed in general procedure A.

Sources & evidence

ORD record
ord-f7538c9cf9804573a4d8da3504dc6e7b
Source dataset
uspto-grants-2006_10
Patent number
US07122580B2

Reaction notes

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