2-Bromophenol → 1-(Benzyloxy)-2-bromobenzene

Participants

Reaction Steps

2-Bromophenol (50.0 g, 0.289 mol) was dissolved in acetone (400 ml), anhydrous potassium carbonate (79.89 g, 0.578 mmol) and benzyl bromide (59.32 g, 0.347 mol) were successively added thereto and the mixture was heated to reflux for 3 hours. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (hexane:AcOEt=95:5) to give the title compound (30.0 g, 0.114 mol, 40%).

Provenance & Evidence