HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 12452Generated: October 25, 2026
Cesium carbonate → 4-Methyl-5-naphthalen-1-yl-thiazole-2-carboxylic acid ethyl ester
https://huagongshe.com/reaction/12452
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1-Naphthaleneboronic acid | HCID 254532 | — |
| Reactant | Ethyl 5-bromo-4-methylthiazole-2-carboxylate | HCID 59338079 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Methyl-5-naphthalen-1-yl-thiazole-2-carboxylic acid ethyl ester | HCID 59338449 | — |
Reaction Steps
To a solution of 5-bromo-4-methyl-thiazole-2-carboxylic acid ethyl ester (60 mg, 0.24 mmol) in 1,4-dioxane (2 ml) is added 1-naphthaleneboronic acid (50 mg, 0.29 mmol), cesium carbonate (187 mg, 0.58 mmol) and Pd(PPh3)4 (28 mg, 0.024 mmol). The reaction mixture is stirred in a sealed tube at 110° C. overnight. After cooling to rt, the mixture is purified by PTLC to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07728009B1 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-9f1c3eae5e914686a5941e976dd60d69 |
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| Source note | uspto-grants-2010_06 |
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