Hydrochloric Acid → 2-Deoxyribose, D-

Participants

Reaction Steps

The pH of the resulting reaction mixture containing the 2-hydroxy-3-deoxy-D-gluconic acid was adjusted to 5.0 with 35% hydrochloric acid solution. Into the reaction mixture was dripped 377 g of 13% sodium hypochlorite solution to perform decarboxylation over a period of 1 hour with the reaction temperature adjusted to 35° C. The pH of the reaction mixture at this time was adjusted between 5 and 6 with acetic acid. After adding the sodium hypochlorite solution, the reaction was carried out for 1 hour to yield 69 g of 2-deoxy-D-ribose. The yield from sodium D-gluconate was 86.3%.

Provenance & Evidence