HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 7-Propyl-3-(trifluoromethyl)-6-(4-bromobutyloxy)-1,2-benzisoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1,4-Dibromobutane | HCID 8056 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 7-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-ol | HCID 135800812 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 7-Propyl-3-(trifluoromethyl)-6-(4-bromobutyloxy)-1,2-benzisoxazole | HCID 21910990 | — |
Reaction Steps
To a DMF solution (50 mL) of 6-hydroxy-7-propyl-3-(trifluoromethyl)-1,2-benzisoxazole as prepared in Example 4 step 2 (6.5 gram, 26.5 mmol) was added 1,4-dibromobutane (16 mL, 133 mmol), followed by cesium carbonate (9.1 grams, 27.8 mmol). The mixture was stirred at room temperature overnight. After aqueous/ether work-up and silica gel chromatography (hexanes: 2.5% ethyl acetate), the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07125865B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-7cfd44608b1741178ad25b377a34f5fa |
| Source note | uspto-grants-2006_10 |