Methylhydantoin-5-(D) → HCID 58719563, compound

HRID 1245317Notes

Reaction equation

[CH3:1][C@H:2]1[NH:6][C:5](=[O:7])[NH:4][C:3]1=[O:8].[CH2:9]([C:12]1[C:20]2[O:19][N:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[C:16]=2[CH:15]=[CH:14][C:13]=1[O:25][CH2:26][CH2:27][CH2:28]Br)[CH2:10][CH3:11]>>[CH3:1][C@H:2]1[NH:6][C:5](=[O:7])[N:4]([CH2:28][CH2:27][CH2:26][O:25][C:13]2[CH:14]=[CH:15][C:16]3[C:17]([C:21]([F:23])([F:24])[F:22])=[N:18][O:19][C:20]=3[C:12]=2[CH2:9][CH2:10][CH3:11])[C:3]1=[O:8]

Participants

Reactant 2

HCID 1615267Methylhydantoin-5-(D)

HCID 12031259HCID 12031259, compound

Product 1

HCID 58719563HCID 58719563, compound

Procedure

5(R)-Methyl-3-(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)imidazolidine-2,4-dione was prepared as for Example 10 from 5(R)-methylimidazolidine-2,4-dione and the bromide from Example 7. After aqueous work-up and silica gel chromatography, the title compound was obtained.

Sources & evidence

ORD record: ord-22579d0581e24443a7cab01e31a75271
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07125865B2

Reaction notes

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