Dimethylhydantoin → HCID 21911011, compound

HRID 1245318Notes

Reaction equation

HRID 1245318 reaction equation
[CH3:1][C:2]1([CH3:9])[NH:6][C:5](=[O:7])[NH:4][C:3]1=[O:8].[CH2:10]([C:13]1[C:21]2[O:20][N:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[C:17]=2[CH:16]=[CH:15][C:14]=1[O:26][CH2:27][CH2:28][CH2:29]Br)[CH2:11][CH3:12]>>[CH3:1][C:2]1([CH3:9])[NH:6][C:5](=[O:7])[N:4]([CH2:29][CH2:28][CH2:27][O:26][C:14]2[CH:15]=[CH:16][C:17]3[C:18]([C:22]([F:24])([F:25])[F:23])=[N:19][O:20][C:21]=3[C:13]=2[CH2:10][CH2:11][CH3:12])[C:3]1=[O:8]

Participants

3

Reactant 2

HCID 6491DimethylhydantoinHCID 120312593-Trifluoromethyl-7-propyl-6-(3-bromopropyloxy)-benzisoxazole

Product 1

HCID 21911011HCID 21911011, compound

Procedure

5,5-Dimethyl-3-(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)imidazolidine-2,4-dione was prepared as for Example 10 from 5,5-dimethylimidazolidine-2,4-dione and the bromide from Example 7. After aqueous work-up and silica gel chromatography, the title compound was obtained.

Sources & evidence

ORD record
ord-5e2d3bbbd6724c7cbb4a1d2a6174a8a1
Source dataset
uspto-grants-2006_10
Patent number
US07125865B2

Reaction notes

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